FILE PHOTO: Surgeon Bartley P. Griffith, MD leads a team conducting a successful transplant of a genetically-modified pig heart on David Bennett, a 57-year-old patient with terminal heart disease, at University of Maryland Medical Center in Baltimore, Maryland, U.S. January 7, 2022. Picture taken January 7, 2022. University of Maryland School of Medicine (UMSOM)/Handout via REUTERS.
The son of a transplant recipient who was implanted with a genetically modified pig heart in a first-of-its-kind surgery, called his father鈥檚 procedure 鈥渁 miracle.鈥�
The surgery, performed by a team at the University of Maryland Medicine on Jan. 7, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools.
If proven successful, scientists hope pig organs could help alleviate shortages of donor organs. For 57-year-old David Bennett of Maryland, the heart transplant was his last option.
鈥淭his is significant for my dad, for the United States, for the world,鈥� David Bennett Jr., the patient鈥檚 son, said on Thursday. 鈥淭his is groundbreaking, this is remarkable and frankly, this is a miracle.鈥�
鈥淚 myself have some heart issues at 37 years old so my dad is certainly changing the future for even myself.鈥�
On the morning of the surgery, the transplant team removed the pig鈥檚 heart and placed it into a special device to preserve its function until the surgery.
鈥淗e was in the operating room three days straight. He鈥檚 got a lot of swelling throughout his body, and so he鈥檚 suffering a great deal. This healing is going to be a process and so again, the first words out of his mouth were 鈥業 can鈥檛 take this鈥� but I know how strong my dad is.鈥�
Pigs have long been a tantalizing source of potential transplants because their organs are so similar to humans.
Prior efforts at pig-to-human transplants have failed because of genetic differences that caused organ rejection or viruses that posed an infection risk.
Scientists have tackled that problem by editing away potentially harmful genes and adding human genes linked with immune acceptance.